Randomized, placebo-controlled trial of bupropion for the treatment of methamphetamine dependence

Steven Shoptaw, Keith G. Heinzerling, Erin Rotheram-Fuller, Trevor Steward, Jason Wang, Aimee Noelle Swanson, Richard De La Garza, Tom Newton, Walter Ling

Research output: Contribution to journalArticlepeer-review

123 Scopus citations


Objective: To compare bupropion to placebo for reducing methamphetamine (MA) use, increasing retention, and reducing the severity of depressive symptoms and MA-cravings. A secondary objective compared bupropion to placebo for reducing cigarette smoking among MA dependent participants. Methods: Following a 2-week, non-medication baseline screening period, 73 treatment-seeking MA dependent participants were randomly assigned to bupropion sustained release (150 mg twice daily; N = 36) or placebo (twice daily; N = 37) for 12-weeks under double-blind conditions. Participants attended clinic thrice weekly to provide urine samples analyzed for MA-metabolite, to complete research measures and assessments, and to receive contingency management and weekly cognitive behavioral therapy sessions. Results: There were no statistically significant effects for bupropion relative to placebo on MA use verified by urine drug screens, for reducing the severity of depressive symptoms or MA-cravings, or on study retention. In a post hoc analysis, there was a statistically significant effect of bupropion treatment on MA use among participants with lighter (0-2 MA-positive urines), but not heavier (3-6 MA-positive urines) MA use during baseline (OR = 2.81, 95% CI = 1.61-4.93, p < 0.001 for MA-free week with bupropion among light users). Bupropion treatment was also associated with significantly reduced cigarette smoking, by almost five cigarettes per day (p = 0.0002). Conclusion: Bupropion was no more effective than placebo in reducing MA use in planned analyses, though bupropion did reduce cigarette smoking. Post hoc findings of an effect for bupropion among baseline light, but not heavy, MA users suggests further evaluation of bupropion for light-MA users is warranted.

Original languageEnglish (US)
Pages (from-to)222-232
Number of pages11
JournalDrug and alcohol dependence
Issue number3
StatePublished - Aug 1 2008
Externally publishedYes


  • Bupropion
  • Methamphetamine dependence
  • Randomized clinical trial

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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