TY - JOUR
T1 - Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging
AU - Hai, Aviad
AU - Spanoudaki, Virginia Ch
AU - Bartelle, Benjamin B.
AU - Jasanoff, Alan
N1 - Funding Information:
This research was funded by NIH grants R01 NS76462, R01 DA038642 and U01 NS904051 to A.J. A.H. was supported by postdoctoral fellowships from the Edmond & Lily Safra Center for Brain Sciences and a long-term fellowship of the European Molecular Biology Organization. We thank A. Takahashi for assistance with 3T MRI measurements.
Publisher Copyright:
© 2018, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Biological electromagnetic fields arise throughout all tissue depths and types, and correlate with physiological processes and signalling in organs of the body. Most of the methods for monitoring these fields are either highly invasive or spatially coarse. Here, we show that implantable active coil-based transducers that are detectable via magnetic resonance imaging enable the remote sensing of biological fields. These devices consist of inductively coupled resonant circuits that change their properties in response to electrical or photonic cues, thereby modulating the local magnetic resonance imaging signal without the need for onboard power or wired connectivity. We discuss design parameters relevant to the construction of the transducers on millimetre and submillimetre scales, and demonstrate their in vivo functionality for measuring time-resolved bioluminescence in rodent brains. Biophysical sensing via microcircuits that leverage the capabilities of magnetic resonance imaging may enable a wide range of biological and biomedical applications.
AB - Biological electromagnetic fields arise throughout all tissue depths and types, and correlate with physiological processes and signalling in organs of the body. Most of the methods for monitoring these fields are either highly invasive or spatially coarse. Here, we show that implantable active coil-based transducers that are detectable via magnetic resonance imaging enable the remote sensing of biological fields. These devices consist of inductively coupled resonant circuits that change their properties in response to electrical or photonic cues, thereby modulating the local magnetic resonance imaging signal without the need for onboard power or wired connectivity. We discuss design parameters relevant to the construction of the transducers on millimetre and submillimetre scales, and demonstrate their in vivo functionality for measuring time-resolved bioluminescence in rodent brains. Biophysical sensing via microcircuits that leverage the capabilities of magnetic resonance imaging may enable a wide range of biological and biomedical applications.
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U2 - 10.1038/s41551-018-0309-8
DO - 10.1038/s41551-018-0309-8
M3 - Article
C2 - 30932065
AN - SCOPUS:85055594446
SN - 2157-846X
VL - 3
SP - 69
EP - 78
JO - Nature Biomedical Engineering
JF - Nature Biomedical Engineering
IS - 1
ER -