Vitellogenin in the honey bee brain: Atypical localization of a reproductive protein that promotes longevity

Daniel Münch; Kate E. Ihle; Heli Salmela; Gro Amdam

doi:10.1016/j.exger.2015.08.001

Vitellogenin in the honey bee brain: Atypical localization of a reproductive protein that promotes longevity

Daniel Münch, Kate E. Ihle, Heli Salmela, Gro Amdam

Life Sciences, School of (SOLS)

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

In comparative gerontology, highly social insects such as honey bees (Apis mellifera) receive much attention due to very different and flexible aging patterns among closely related siblings. While experimental strategies that manipulate socio-environmental factors suggest a causative link between aging and social signals and behaviors, the molecular underpinnings of this linkage are less well understood. Here we study the atypical localization of the egg-yolk protein vitellogenin (Vg) in the brain of the honey bee. Vg is known to influence honey bee social regulation and aging rate. Our findings suggest that Vg immunoreactivity in the brain is specifically localized within the class of non-neuronal glial cells. We discuss how these results can help explain the socially-dependent aging rate of honey bees.

Original language	English (US)
Pages (from-to)	103-108
Number of pages	6
Journal	Experimental Gerontology
Volume	71
DOIs	https://doi.org/10.1016/j.exger.2015.08.001
State	Published - Jun 20 2015

Keywords

Aging
Glial cells
Insects
Lipid transport proteins

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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10.1016/j.exger.2015.08.001

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title = "Vitellogenin in the honey bee brain: Atypical localization of a reproductive protein that promotes longevity",

abstract = "In comparative gerontology, highly social insects such as honey bees (Apis mellifera) receive much attention due to very different and flexible aging patterns among closely related siblings. While experimental strategies that manipulate socio-environmental factors suggest a causative link between aging and social signals and behaviors, the molecular underpinnings of this linkage are less well understood. Here we study the atypical localization of the egg-yolk protein vitellogenin (Vg) in the brain of the honey bee. Vg is known to influence honey bee social regulation and aging rate. Our findings suggest that Vg immunoreactivity in the brain is specifically localized within the class of non-neuronal glial cells. We discuss how these results can help explain the socially-dependent aging rate of honey bees.",

keywords = "Aging, Glial cells, Insects, Lipid transport proteins",

author = "Daniel M{\"u}nch and Ihle, {Kate E.} and Heli Salmela and Gro Amdam",

note = "Funding Information: This work was supported by grants from the Research Council of Norway (project ID 213976 ), a Leiv Eiriksson mobility grant to Kate Ihle, and by Finnish Academy (grant 265971 ). We thank the Imaging Centre Campus {\AA}s, Department of Plant Sciences, NMBU (Hilde Kolstad, NMBU) for the assistance with microscopic sample preparation, and Marije Oostindjer for comments on the manuscript. We want to thank Joachim Urban (Johannes Gutenberg-Universit{\"a}t Mainz, Germany) and Ashish K. Shah for the anti-REPO antibody, and for performing glial specific histology, respectively. Many thanks to the editor and the two anonymous reviewers for their valuable comments. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

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doi = "10.1016/j.exger.2015.08.001",

language = "English (US)",

volume = "71",

pages = "103--108",

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AU - Salmela, Heli

AU - Amdam, Gro

N1 - Funding Information: This work was supported by grants from the Research Council of Norway (project ID 213976 ), a Leiv Eiriksson mobility grant to Kate Ihle, and by Finnish Academy (grant 265971 ). We thank the Imaging Centre Campus Ås, Department of Plant Sciences, NMBU (Hilde Kolstad, NMBU) for the assistance with microscopic sample preparation, and Marije Oostindjer for comments on the manuscript. We want to thank Joachim Urban (Johannes Gutenberg-Universität Mainz, Germany) and Ashish K. Shah for the anti-REPO antibody, and for performing glial specific histology, respectively. Many thanks to the editor and the two anonymous reviewers for their valuable comments. Publisher Copyright: © 2015 Elsevier Inc.

PY - 2015/6/20

Y1 - 2015/6/20

N2 - In comparative gerontology, highly social insects such as honey bees (Apis mellifera) receive much attention due to very different and flexible aging patterns among closely related siblings. While experimental strategies that manipulate socio-environmental factors suggest a causative link between aging and social signals and behaviors, the molecular underpinnings of this linkage are less well understood. Here we study the atypical localization of the egg-yolk protein vitellogenin (Vg) in the brain of the honey bee. Vg is known to influence honey bee social regulation and aging rate. Our findings suggest that Vg immunoreactivity in the brain is specifically localized within the class of non-neuronal glial cells. We discuss how these results can help explain the socially-dependent aging rate of honey bees.

AB - In comparative gerontology, highly social insects such as honey bees (Apis mellifera) receive much attention due to very different and flexible aging patterns among closely related siblings. While experimental strategies that manipulate socio-environmental factors suggest a causative link between aging and social signals and behaviors, the molecular underpinnings of this linkage are less well understood. Here we study the atypical localization of the egg-yolk protein vitellogenin (Vg) in the brain of the honey bee. Vg is known to influence honey bee social regulation and aging rate. Our findings suggest that Vg immunoreactivity in the brain is specifically localized within the class of non-neuronal glial cells. We discuss how these results can help explain the socially-dependent aging rate of honey bees.

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KW - Insects

KW - Lipid transport proteins

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Vitellogenin in the honey bee brain: Atypical localization of a reproductive protein that promotes longevity

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Keywords

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