Vitamin D Nutrient-Gene Interactions and Healthful Aging

Mark R. Haussler; Rimpi K. Saini; Marya S. Sabir; Christopher M. Dussik; Zainab Khan; G. Kerr Whitfield; Kristin P. Griffin; Ichiro Kaneko; Peter Jurutka

doi:10.1016/B978-0-12-801816-3.00033-9

Vitamin D Nutrient-Gene Interactions and Healthful Aging

Mark R. Haussler, Rimpi K. Saini, Marya S. Sabir, Christopher M. Dussik, Zainab Khan, G. Kerr Whitfield, Kristin P. Griffin, Ichiro Kaneko, Peter Jurutka

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

1,25-Dihydroxyvitamin D₃ (1,25D) is the endocrine metabolite of vitamin D that signals through binding to the vitamin D receptor (VDR). The ligand-receptor complex transcriptionally regulates genes that encode factors promoting intestinal calcium and phosphate absorption plus bone remodeling, maintaining a skeleton with reduced risk of age-related osteoporotic fractures. 1,25D/VDR signaling further exerts feedback control of mineral ions via regulation of FGF23, klotho, and CYP24A1 to prevent age-related, ectopic calcification, and associated pathologies. Vitamin D also elicits xenobiotic detoxification, oxidative stress reduction, antimicrobial defense, immunoregulation, anti-inflammatory/anticancer actions, and cardiovascular benefits. 1,25D exerts neuroprotective actions against excitotoxicity, and induces serotonin mood elevator to support cognitive function and prosocial behavior. Nutrient, low-affinity VDR ligands including curcumin, polyunsaturated fatty acids, and delphinidin/anthocyanidins initiate VDR signaling, whereas longevity agents such as resveratrol and SIRT1 potentiate VDR signaling. Therefore, liganded VDR modulates the expression of a network of genes that facilitates health span by delaying the chronic diseases of aging.

Original language	English (US)
Title of host publication	Molecular Basis of Nutrition and Aging
Subtitle of host publication	A Volume in the Molecular Nutrition Series
Publisher	Elsevier Inc.
Pages	449-471
Number of pages	23
ISBN (Electronic)	9780128018279
ISBN (Print)	9780128018163
DOIs	https://doi.org/10.1016/B978-0-12-801816-3.00033-9
State	Published - Apr 28 2016

Keywords

1,25-Dihydroxyvitamin D
Anti-inflammatory
Anticancer nutrient
Ectopic calcification
FGF23
Klotho
Neuroprotection
Osteoporosis
Vitamin D receptor

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-0-12-801816-3.00033-9

Cite this

@inbook{1bee0af71ff84b5094a8f8640ea791b0,

title = "Vitamin D Nutrient-Gene Interactions and Healthful Aging",

abstract = "1,25-Dihydroxyvitamin D3 (1,25D) is the endocrine metabolite of vitamin D that signals through binding to the vitamin D receptor (VDR). The ligand-receptor complex transcriptionally regulates genes that encode factors promoting intestinal calcium and phosphate absorption plus bone remodeling, maintaining a skeleton with reduced risk of age-related osteoporotic fractures. 1,25D/VDR signaling further exerts feedback control of mineral ions via regulation of FGF23, klotho, and CYP24A1 to prevent age-related, ectopic calcification, and associated pathologies. Vitamin D also elicits xenobiotic detoxification, oxidative stress reduction, antimicrobial defense, immunoregulation, anti-inflammatory/anticancer actions, and cardiovascular benefits. 1,25D exerts neuroprotective actions against excitotoxicity, and induces serotonin mood elevator to support cognitive function and prosocial behavior. Nutrient, low-affinity VDR ligands including curcumin, polyunsaturated fatty acids, and delphinidin/anthocyanidins initiate VDR signaling, whereas longevity agents such as resveratrol and SIRT1 potentiate VDR signaling. Therefore, liganded VDR modulates the expression of a network of genes that facilitates health span by delaying the chronic diseases of aging.",

keywords = "1,25-Dihydroxyvitamin D, Anti-inflammatory, Anticancer nutrient, Ectopic calcification, FGF23, Klotho, Neuroprotection, Osteoporosis, Vitamin D receptor",

author = "Haussler, {Mark R.} and Saini, {Rimpi K.} and Sabir, {Marya S.} and Dussik, {Christopher M.} and Zainab Khan and Whitfield, {G. Kerr} and Griffin, {Kristin P.} and Ichiro Kaneko and Peter Jurutka",

year = "2016",

month = apr,

day = "28",

doi = "10.1016/B978-0-12-801816-3.00033-9",

language = "English (US)",

isbn = "9780128018163",

pages = "449--471",

booktitle = "Molecular Basis of Nutrition and Aging",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Vitamin D Nutrient-Gene Interactions and Healthful Aging

AU - Haussler, Mark R.

AU - Saini, Rimpi K.

AU - Sabir, Marya S.

AU - Dussik, Christopher M.

AU - Khan, Zainab

AU - Whitfield, G. Kerr

AU - Griffin, Kristin P.

AU - Kaneko, Ichiro

AU - Jurutka, Peter

PY - 2016/4/28

Y1 - 2016/4/28

N2 - 1,25-Dihydroxyvitamin D3 (1,25D) is the endocrine metabolite of vitamin D that signals through binding to the vitamin D receptor (VDR). The ligand-receptor complex transcriptionally regulates genes that encode factors promoting intestinal calcium and phosphate absorption plus bone remodeling, maintaining a skeleton with reduced risk of age-related osteoporotic fractures. 1,25D/VDR signaling further exerts feedback control of mineral ions via regulation of FGF23, klotho, and CYP24A1 to prevent age-related, ectopic calcification, and associated pathologies. Vitamin D also elicits xenobiotic detoxification, oxidative stress reduction, antimicrobial defense, immunoregulation, anti-inflammatory/anticancer actions, and cardiovascular benefits. 1,25D exerts neuroprotective actions against excitotoxicity, and induces serotonin mood elevator to support cognitive function and prosocial behavior. Nutrient, low-affinity VDR ligands including curcumin, polyunsaturated fatty acids, and delphinidin/anthocyanidins initiate VDR signaling, whereas longevity agents such as resveratrol and SIRT1 potentiate VDR signaling. Therefore, liganded VDR modulates the expression of a network of genes that facilitates health span by delaying the chronic diseases of aging.

AB - 1,25-Dihydroxyvitamin D3 (1,25D) is the endocrine metabolite of vitamin D that signals through binding to the vitamin D receptor (VDR). The ligand-receptor complex transcriptionally regulates genes that encode factors promoting intestinal calcium and phosphate absorption plus bone remodeling, maintaining a skeleton with reduced risk of age-related osteoporotic fractures. 1,25D/VDR signaling further exerts feedback control of mineral ions via regulation of FGF23, klotho, and CYP24A1 to prevent age-related, ectopic calcification, and associated pathologies. Vitamin D also elicits xenobiotic detoxification, oxidative stress reduction, antimicrobial defense, immunoregulation, anti-inflammatory/anticancer actions, and cardiovascular benefits. 1,25D exerts neuroprotective actions against excitotoxicity, and induces serotonin mood elevator to support cognitive function and prosocial behavior. Nutrient, low-affinity VDR ligands including curcumin, polyunsaturated fatty acids, and delphinidin/anthocyanidins initiate VDR signaling, whereas longevity agents such as resveratrol and SIRT1 potentiate VDR signaling. Therefore, liganded VDR modulates the expression of a network of genes that facilitates health span by delaying the chronic diseases of aging.

KW - 1,25-Dihydroxyvitamin D

KW - Anti-inflammatory

KW - Anticancer nutrient

KW - Ectopic calcification

KW - FGF23

KW - Klotho

KW - Neuroprotection

KW - Osteoporosis

KW - Vitamin D receptor

UR - http://www.scopus.com/inward/record.url?scp=84978347263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978347263&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-801816-3.00033-9

DO - 10.1016/B978-0-12-801816-3.00033-9

M3 - Chapter

AN - SCOPUS:84978347263

SN - 9780128018163

SP - 449

EP - 471

BT - Molecular Basis of Nutrition and Aging

PB - Elsevier Inc.

ER -

Vitamin D Nutrient-Gene Interactions and Healthful Aging

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this