Veal heart ribonuclease P has an essential RNA component

Eiko Akaboshi, Cecilia Guerrier-Takada, Sidney Altman

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The activity of RNase P (EC from veal heart can be abolished by pretreatment of the enzyme preparation with micrococcal nuclease, pancreatic RNase A, or RNase T1. This indicates that veal heart RNase P contains an RNA component essential for function of the enzyme as has also been shown for E. coli RNase P (1–3). Additionally, veal heart RNase P has a buoyant density in Cs2SO4 of 1.33 g/cm3, which is intermediate between that of protein and nucleic acid.

Original languageEnglish (US)
Pages (from-to)831-837
Number of pages7
JournalTopics in Catalysis
Issue number2
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Biophysics
  • Molecular Biology


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