Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples

Peter B. Barr, Albert Ksinan, Jinni Su, Emma C. Johnson, Jacquelyn L. Meyers, Leah Wetherill, Antti Latvala, Fazil Aliev, Grace Chan, Samuel Kuperman, John Nurnberger, Chella Kamarajan, Andrey Anokhin, Arpana Agrawal, Richard J. Rose, Howard J. Edenberg, Marc Schuckit, Jaakko Kaprio, Danielle M. Dick

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Genome-wide, polygenic risk scores (PRS) have emerged as a useful way to characterize genetic liability. There is growing evidence that PRS may prove useful for early identification of those at increased risk for certain diseases. The current potential of PRS for alcohol use disorders (AUD) remains an open question. Using data from both a population-based sample [the FinnTwin12 (FT12) study] and a high-risk sample [the Collaborative Study on the Genetics of Alcoholism (COGA)], we examined the association between PRSs derived from genome-wide association studies (GWASs) of (1) alcohol dependence/alcohol problems, (2) alcohol consumption, and (3) risky behaviors with AUD and other substance use disorder (SUD) criteria. These PRSs explain ~2.5–3.5% of the variance in AUD (across FT12 and COGA) when all PRSs are included in the same model. Calculations of area under the curve (AUC) show PRS provide only a slight improvement over a model with age, sex, and ancestral principal components as covariates. While individuals in the top 20, 10, and 5% of the PRS distribution had greater odds of having an AUD compared to the lower end of the continuum in both COGA and FT12, the point estimates at each threshold were statistically indistinguishable. Those in the top 5% reported greater levels of licit (alcohol and nicotine) and illicit (cannabis and opioid) SUD criteria. PRSs are associated with risk for SUD in independent samples. However, usefulness for identifying those at increased risk in their current form is modest, at best. Improvement in predictive ability will likely be dependent on increasing the size of well-phenotyped discovery samples.

Original languageEnglish (US)
Article number196
JournalTranslational Psychiatry
Issue number1
StatePublished - Dec 1 2020

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry


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