Universal method for conjugation of oligonucleotide to quantum dots spanning from UV-vis to IR emission spectrum

Yan Liu (Inventor), Hao Yan (Inventor)

Research output: Patent


Adding DNA to nanotechnology enables the creation of versatile, complex and programmable nanoparticles. It is common to chemically immobilize ssDNA on metallic gold (Au) nanoparticles (AuNP) to construct, one, two, three-dimensional and even chiral AuNP architectures. Although much research has been devoted to this area, and there has been successful ssDNA-AuNP conjugation, the conjugation of DNA to other nanoparticles, such as quantum dots (QDs), has been a significant challenge, and until now, has not been achieved in a simple and reliable manner. Researchers at the Biodesign Institute of Arizona State University have developed a novel method for creating stable highly fluorescent semiconductor nanoparticle-ssDNA conjugates. The semiconductor nanoparticles can include quantum dots, quantum wires, quantum ribbons or quantum sheets, with highly tunable and bright photoluminescence spanning from UV to visible to IR. These conjugates could be programmably positioned on addressable DNA origami through direct complementary base-pairing hybridization. This technology opens up new opportunities to construct multicomponent discrete semiconductor or semiconductor-metal hybrid nanostructures for a wide variety of applications including imaging, nanophotonics, biosensing, etc. Potential Applications Conjugating ssDNA to quantum dots, ribbons, sheets, wires and rods Bioimaging & staining Molecular detection Nanophotonics Biosensing Energy Benefits and Advantages Simple and reliable conjugation method Efficient Water-soluble Spans the full spectrum of QD emissions from UV-vis to IR Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Yan's departmental webpage Dr. Yan's laboratory webpage Dr. Liu's departmental webpage
Original languageEnglish (US)
StatePublished - May 3 2012


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