TY - JOUR
T1 - Ultrathin Layered Hyperbolic Metamaterial-Assisted Illumination Nanoscopy
AU - Lee, Yeon Ui
AU - Nie, Zhaoyu
AU - Li, Shilong
AU - Lambert, Charles Henri
AU - Zhao, Junxiang
AU - Yang, Fan
AU - Wisna, G. Bimananda M.
AU - Yang, Sui
AU - Zhang, Xiang
AU - Liu, Zhaowei
N1 - Funding Information:
This work was supported by the Gordon and Betty Moore Foundation (to Z.L.). Y.U.L. acknowledges NRF Grant (2014M3A6B3063708, 2021R1F1A1062916).
Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/7/27
Y1 - 2022/7/27
N2 - Metamaterial-assisted illumination nanoscopy (MAIN) has been proven to be a promising approach for super-resolution microscopy with up to a 7-fold improvement in imaging resolution. Further resolution enhancement is possible in principle, however, has not yet been demonstrated due to the lack of high-quality ultrathin layered hyperbolic metamaterials (HMMs) used in the MAIN. Here, we fabricate a low-loss composite HMM consisting of high-quality bilayers of Al-doped Ag and MgO with a nominal thickness of 2.5 nm, and then use it to demonstrate an ultrathin layered hyperbolic metamaterial-assisted illumination nanoscopy (ULH-MAIN) with a 14-fold imaging resolution improvement. This improvement of resolution is achieved in fluorescent beads super-resolution experiments and verified with scanning electron microscopy. The ULH-MAIN presents a simple super-resolution imaging approach that offers distinct benefits such as low illumination power, low cost, and a broad spectrum of selectable probes, making it ideal for dynamic imaging of life science samples.
AB - Metamaterial-assisted illumination nanoscopy (MAIN) has been proven to be a promising approach for super-resolution microscopy with up to a 7-fold improvement in imaging resolution. Further resolution enhancement is possible in principle, however, has not yet been demonstrated due to the lack of high-quality ultrathin layered hyperbolic metamaterials (HMMs) used in the MAIN. Here, we fabricate a low-loss composite HMM consisting of high-quality bilayers of Al-doped Ag and MgO with a nominal thickness of 2.5 nm, and then use it to demonstrate an ultrathin layered hyperbolic metamaterial-assisted illumination nanoscopy (ULH-MAIN) with a 14-fold imaging resolution improvement. This improvement of resolution is achieved in fluorescent beads super-resolution experiments and verified with scanning electron microscopy. The ULH-MAIN presents a simple super-resolution imaging approach that offers distinct benefits such as low illumination power, low cost, and a broad spectrum of selectable probes, making it ideal for dynamic imaging of life science samples.
KW - Hyperbolic metamaterials
KW - Metamaterial assisted illumination
KW - Metamaterials
KW - Nanoscopy
KW - Structured illumination microscopy
KW - Super-resolution microscopy
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U2 - 10.1021/acs.nanolett.2c01932
DO - 10.1021/acs.nanolett.2c01932
M3 - Article
C2 - 35834181
AN - SCOPUS:85134871695
SN - 1530-6984
VL - 22
SP - 5916
EP - 5921
JO - Nano Letters
JF - Nano Letters
IS - 14
ER -