Abstract
(Figure Presented) The highs and lows of proteins: A dramatically amplified aptamer-based bioelectronic assay has been developed that allows the ultrasensitive measurement of thrombin down to the femtomolar level. This label-free electronic detection of thrombin takes advantage of the intrinsic electroactivity of a second aptamer with guanine bases, and the enormous amplification feature of the polymerase chain reaction (PCR, see picture).
Original language | English (US) |
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Pages (from-to) | 9054-9056 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 47 |
DOIs | |
State | Published - 2007 |
Keywords
- Aptamers
- Bioelectronics
- Guanine
- Polymerase chain reaction
- Proteins
ASJC Scopus subject areas
- Catalysis
- General Chemistry