Ultrasensitive label-free aptamer-based electronic detection

Yun Xiang, Mingyi Xie, Ralph Bash, Julian Chen, Joseph Wang

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


(Figure Presented) The highs and lows of proteins: A dramatically amplified aptamer-based bioelectronic assay has been developed that allows the ultrasensitive measurement of thrombin down to the femtomolar level. This label-free electronic detection of thrombin takes advantage of the intrinsic electroactivity of a second aptamer with guanine bases, and the enormous amplification feature of the polymerase chain reaction (PCR, see picture).

Original languageEnglish (US)
Pages (from-to)9054-9056
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number47
StatePublished - 2007


  • Aptamers
  • Bioelectronics
  • Guanine
  • Polymerase chain reaction
  • Proteins

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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