Two-state migration of DNA in a structured microchannel

Martin Streek, Friederike Schmid, Thanh Tu Duong, Dario Anselmetti, Alexandra Ros

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


DNA migration in topologically structured microchannels with periodic cavities is investigated experimentally and with Brownian dynamics simulations of a simple bead-spring model. The results are in very good agreement with one another. In particular, the experimentally observed migration order oλ- and T2-DNA molecules is reproduced by the simulations. The simulation data indicate that the mobility may depend on the chain length in a nonmonotonic way at high electric fields. This is found to be the signature of a nonequilibrium bistability between two different migration states, a slow one and a fast one. The latter can also be observed experimentally under appropriate conditions.

Original languageEnglish (US)
Article number011905
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Issue number1
StatePublished - Jan 2005
Externally publishedYes

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics


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