Trophic factors for Parkinson's disease: To live or let die

C. Warren Olanow, Raymond T. Bartus, Laura A. Volpicelli-Daley, Jeffrey H. Kordower

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Trophic factors show great promise in laboratory studies as potential therapies for PD. However, multiple double-blind, clinical trials have failed to show benefits in comparison to a placebo control. This article will review the scientific rationale for testing trophic factors in PD, the results of the different clinical trials that have been performed to date, and the possible explanations for these failed outcomes. We will also consider future directions and the likelihood that trophic factors will become a viable therapy for patients with PD.

Original languageEnglish (US)
Pages (from-to)1715-1724
Number of pages10
JournalMovement Disorders
Issue number13
StatePublished - Nov 1 2015
Externally publishedYes


  • Trophic Factors; Parkinson's Disease; GDNF; Neurturin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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