TY - JOUR
T1 - Triglyceride screening may improve cardiometabolic disease risk assessment in latinos with poorly controlled type 2 diabetes
AU - Vega-Lopez, Sonia
AU - Calle, Mariana C.
AU - Fernandez, Maria Luz
AU - Kollannoor-Samuel, Grace
AU - Chhabra, Jyoti
AU - Todd, Michael
AU - Segura-Pérez, Sofia
AU - D'Agostino, Darrin
AU - Damio, Grace
AU - Pérez-Escamilla, Rafael
PY - 2013
Y1 - 2013
N2 - To characterize metabolic syndrome (MetS) prevalence and cardiometabolic risk, HbA1c, fasting plasma glucose (FPG), plasma lipids, blood pressure, BMI, and waist circumference were measured in 211 Latino adults wiThtype 2 diabetes. Participants were obese (BMI=33.7±7.8 kg/ m2) and had poor glycemic control (HbA1c=9.6±1.8 %; FPG=190±85 mg/ dL), but normal LDL and HDL cholesterol concentrations (98±38 mg/ dL, and 52±14 mg/ dL, respectively). Relative to the lowest, participants in the highest quintile of plasma triglycierides had higher total cholesterol (23%; p<.0001), FPG (47%; p<.0001), systolic blood pressure (3%; p<.05) and diastolic blood pressure (6%; p<.05), and lower HDL cholesterol (23%; p<.01). Comparable relationships were observed in an age- adjusted regression model. Framingham risk was equivalent to 9.4±6.4% and 12.2±9.6% 10-year CHD risk in men and women, respectively (p<.05). Cardiometabolic risk in this population is associated wiTha high prevalence of the MetS despite the relatively low cholesterol concentrations. Triglyceride screening may help identify individuals at higher risk.
AB - To characterize metabolic syndrome (MetS) prevalence and cardiometabolic risk, HbA1c, fasting plasma glucose (FPG), plasma lipids, blood pressure, BMI, and waist circumference were measured in 211 Latino adults wiThtype 2 diabetes. Participants were obese (BMI=33.7±7.8 kg/ m2) and had poor glycemic control (HbA1c=9.6±1.8 %; FPG=190±85 mg/ dL), but normal LDL and HDL cholesterol concentrations (98±38 mg/ dL, and 52±14 mg/ dL, respectively). Relative to the lowest, participants in the highest quintile of plasma triglycierides had higher total cholesterol (23%; p<.0001), FPG (47%; p<.0001), systolic blood pressure (3%; p<.05) and diastolic blood pressure (6%; p<.05), and lower HDL cholesterol (23%; p<.01). Comparable relationships were observed in an age- adjusted regression model. Framingham risk was equivalent to 9.4±6.4% and 12.2±9.6% 10-year CHD risk in men and women, respectively (p<.05). Cardiometabolic risk in this population is associated wiTha high prevalence of the MetS despite the relatively low cholesterol concentrations. Triglyceride screening may help identify individuals at higher risk.
KW - Cardiovascular disease risk
KW - Latinos
KW - Metabolic syndrome
KW - Type 2 diabetes
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U2 - 10.1353/hpu.2013.0171
DO - 10.1353/hpu.2013.0171
M3 - Article
C2 - 24185167
AN - SCOPUS:84887053360
SN - 1049-2089
VL - 24
SP - 1739
EP - 1755
JO - Journal of health care for the poor and underserved
JF - Journal of health care for the poor and underserved
IS - 4
ER -