Transmission and dynamics of tuberculosis on generalized households

Juan P. Aparicio, Angel F. Capurro, Carlos Castillo-Chavez

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Tuberculosis (TB) transmission is enhanced by systematic exposure to an infectious individual. This enhancement usually takes place at either the home, workplace, and/or school (generalized household). Typical epidemiological models do not incorporate the impact of generalized households on the study of disease dynamics. Models that incorporate cluster (generalized household) effects and focus on their impact on TB's transmission dynamics are developed. Detailed models that consider the effect of casual infections, that is, those generated outside a cluster, are also presented. We find expressions for the Basic Reproductive Number as a function of cluster size. The formula for R0 separates the contributions of cluster and casual infections in the generation of secondary TB infections. Relationships between cluster and classical epidemic models are discussed as well as the concept of critical cluster size. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)327-341
Number of pages15
JournalJournal of Theoretical Biology
Issue number3
StatePublished - Oct 7 2000
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences
  • Applied Mathematics


Dive into the research topics of 'Transmission and dynamics of tuberculosis on generalized households'. Together they form a unique fingerprint.

Cite this