Towards patient-friendly input signal design for optimized pain treatment interventions

Sunil Deshpande, Daniel Rivera, Jarred Younger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

16 Scopus citations


We examine some of the challenges associated with generating input signals for identifying dynamics in pain treatment interventions while imposing "patient-friendly" constraints on the design. Standard clinical trials, while providing some useful information, are not the most suitable vehicle for understanding the dynamic response of dosage changes to participant response. Meanwhile, much of the work in classical input design, even that which incorporates "plant-friendly" considerations, may not result in clinically acceptable trials for human participants. In this paper, we describe some of the issues involved and suggest various approaches (leading ultimately to optimization-based formulations) to obtain input signals with desired spectral properties under time-domain constraints of importance to clinical practice. Numerical examples are shown to illustrate the proposed method with a hypothetical clinical trial of the drug gabapentin for the treatment of neuropathic pain.

Original languageEnglish (US)
Title of host publicationSYSID 2012 - 16th IFAC Symposium on System Identification, Final Program
PublisherIFAC Secretariat
Number of pages6
EditionPART 1
ISBN (Print)9783902823069
StatePublished - 2012
EventUniversite Libre de Bruxelles - Bruxelles, Belgium
Duration: Jul 11 2012Jul 13 2012

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
NumberPART 1
ISSN (Print)1474-6670


OtherUniversite Libre de Bruxelles


  • Biomedical systems
  • Medical applications
  • Optimal experiment design
  • Optimization problems

ASJC Scopus subject areas

  • Control and Systems Engineering


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