TY - JOUR
T1 - Toward anticipatory governance of human genome editing
T2 - a critical review of scholarly governance discourse
AU - Nelson, John P.
AU - Selin, Cynthia L.
AU - Scott, Christopher T.
N1 - Funding Information:
This work was supported by National Institutes of Health [grant number 1R01HG010332-01A1]; National Science Foundation [grant number 1841051]. We are grateful to Dave Guston and Dan Sarewitz for critical and helpful comments on earlier drafts of this paper, to Ben Hurlbut and Christian Ross for suggestions during the literature review process, and to Avery Barbera for assistance with citation formatting. We are grateful as well to our anonymous reviewers and to the editors of The Journal of Responsible Innovation for generative critique and suggestions on the manuscript. Finally, we wish to acknowledge our full project team, which includes Stephanie Morain, Mahmud Farooque, David Tomblin, David Sittenfeld, Haley Manley, Dorit Barlevy, and Lauren Lambert. Any remaining errors, of course, are our own.
Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - The rapid development of human genome editing (HGE) techniques evokes an urgent need for forward-looking deliberation regarding the aims, processes, and governance of research. The framework of anticipatory governance (AG) may serve this need. This article reviews scholarly discourse about HGE through an AG lens, aiming to identify gaps in discussion and practice and suggest how AG efforts may fill them. Discourse on HGE has insufficiently reckoned with the institutional and systemic contexts, inputs, and implications of HGE work, to the detriment of its ability to prepare for a variety of possible futures and pursue socially desirable ones. More broadly framed and inclusive efforts in foresight and public engagement, focused not only upon the in-principle permissibility of HGE activities but upon the contexts of such work, may permit improved identification of public values relevant to HGE and of actions by which researchers, funders, policymakers, and publics may promote them.
AB - The rapid development of human genome editing (HGE) techniques evokes an urgent need for forward-looking deliberation regarding the aims, processes, and governance of research. The framework of anticipatory governance (AG) may serve this need. This article reviews scholarly discourse about HGE through an AG lens, aiming to identify gaps in discussion and practice and suggest how AG efforts may fill them. Discourse on HGE has insufficiently reckoned with the institutional and systemic contexts, inputs, and implications of HGE work, to the detriment of its ability to prepare for a variety of possible futures and pursue socially desirable ones. More broadly framed and inclusive efforts in foresight and public engagement, focused not only upon the in-principle permissibility of HGE activities but upon the contexts of such work, may permit improved identification of public values relevant to HGE and of actions by which researchers, funders, policymakers, and publics may promote them.
KW - CRISPR
KW - Human genome editing
KW - participatory governance
KW - public engagement
KW - responsible innovation
KW - technology foresight
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U2 - 10.1080/23299460.2021.1957579
DO - 10.1080/23299460.2021.1957579
M3 - Article
AN - SCOPUS:85111649622
SN - 2329-9460
VL - 8
SP - 382
EP - 420
JO - Journal of Responsible Innovation
JF - Journal of Responsible Innovation
IS - 3
ER -