TY - JOUR
T1 - The under-appreciated world of the serpin family of serine proteinase inhibitors
AU - Bouton, Marie Christine
AU - Geiger, Margarethe
AU - Sheffield, William P.
AU - Irving, James A.
AU - Lomas, David A.
AU - Song, Sihong
AU - Satyanarayanan, Ritvik S.
AU - Zhang, Liqiang
AU - McFadden, Grant
AU - Lucas, Alexandra R.
N1 - Publisher Copyright:
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
PY - 2023/6/7
Y1 - 2023/6/7
N2 - In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors that, in turn, regulate these proteases. The serpins are a family of proteins with a shared tertiary structure, whose members largely act as serine protease inhibitors, found in all forms of life, ranging from viruses, bacteria, and archaea to plants and animals. These proteins represent up to 2–10% of proteins in the human blood and are the third most common protein family.
AB - In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors that, in turn, regulate these proteases. The serpins are a family of proteins with a shared tertiary structure, whose members largely act as serine protease inhibitors, found in all forms of life, ranging from viruses, bacteria, and archaea to plants and animals. These proteins represent up to 2–10% of proteins in the human blood and are the third most common protein family.
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U2 - 10.15252/emmm.202217144
DO - 10.15252/emmm.202217144
M3 - Comment/debate
C2 - 37158379
AN - SCOPUS:85158882566
SN - 1757-4676
VL - 15
JO - EMBO Molecular Medicine
JF - EMBO Molecular Medicine
IS - 6
M1 - e17144
ER -