The tumor microenvironment in colorectal carcinogenesis

Vijay G. Peddareddigari, Dingzhi Wang, Raymond N. Dubois

Research output: Contribution to journalArticlepeer-review

172 Scopus citations


Colorectal cancer is the second leading cause of cancer-related mortality in the United States. Therapeutic developments in the past decade have extended life expectancy in patients with metastatic disease. However, metastatic colorectal cancers remain incurable. Numerous agents that were demonstrated to have significant antitumor activity in experimental models translated into disappointing results in extending patient survival. This has resulted in more attention being focused on the contribution of tumor microenvironment to the progression of a number of solid tumors including colorectal cancer. A more complete understanding of interactions between tumor epithelial cells and their stromal elements will enhance therapeutic options and improve clinical outcome. Here we will review the role of various stromal components in colorectal carcinogenesis and discuss the potential of targeting these components for the development of future therapeutic agents.

Original languageEnglish (US)
Pages (from-to)149-166
Number of pages18
JournalCancer Microenvironment
Issue number1
StatePublished - Dec 2010
Externally publishedYes


  • Colon cancer
  • Extracellular matrix
  • Stroma
  • Tumor infiltrating cells
  • Tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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