@article{95111964fb6141ce8b4629b02e850af2,
title = "The role of variants from the innate immune system genes in tuberculosis and skin test response in a Native American population",
abstract = "Native American populations show higher tuberculosis (TB) mortality and infectivity rates than non-Native populations. Variants in the innate immune system seem to have an important role on TB susceptibility. The role of some innate immune system variants in TB susceptibility and/or skin test response (PPD) were investigated in the Ach{\'e}, a Native American population. Complement receptor 1 and toll like receptor 9 variants were associated with anergy to PPD and protection to TB, respectively. These findings demonstrate an important role of the innate immune system variants in TB susceptibility.",
keywords = "Amerindians, CR1, Innate immunity, TLR9, Tuberculosis",
author = "Lindenau, {Juliana D.} and Salzano, {Francisco M.} and Ana Hurtado and Kim Hill and Hutz, {Mara H.}",
note = "Funding Information: The Amerindian leaders and the subjects of the investigation were adequately informed about the aims of the study and gave their approval, which is gratefully acknowledged. Our research program was approved by the Brazilian Ethics National Committee (Resolution 123/98). The authors thank Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq, Brazil) and Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior (CAPES – Brazil) for financial support. Publisher Copyright: {\textcopyright} 2016 American Society for Histocompatibility and Immunogenetics",
year = "2016",
month = oct,
day = "1",
doi = "10.1016/j.humimm.2016.06.017",
language = "English (US)",
volume = "77",
pages = "981--984",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",
number = "10",
}