The Role of Prostaglandin E2 in Tumor-Associated Immunosuppression

Dingzhi Wang, Raymond N. DuBois

Research output: Contribution to journalShort surveypeer-review

78 Scopus citations


Tumor-associated inflammation can create an immunosuppressive microenvironment allowing tumor cells to escape immunosurveillance. Inhibiting immunosuppression remains one of the major challenges in cancer immunotherapy via checkpoint inhibitors. Recent preclinical data from the Reis e Sousa group may provide a strong rationale for developing new therapeutics to subvert tumor-induced immunosuppression via prostaglandin inhibition.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalTrends in Molecular Medicine
Issue number1
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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