The role of astrogliosis in formation of the syrinx in spinal cord injury

Jacek M. Kwiecien, Wojciech Dąbrowski, Jordan R. Yaron, Liqiang Zhang, Kathleen H. Delaney, Alexandra R. Lucas

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


A massive localized trauma to the spinal cord results in complex pathologic events driv-en by necrosis and vascular damage which in turn leads to hemorrhage and edema. Severe, destruc-tive and very protracted inflammatory response is characterized by infiltration by phagocytic macrophages of a site of injury which is converted into a cavity of injury (COI) surrounded by as-troglial reaction mounted by the spinal cord. The tissue response to the spinal cord injury (SCI) has been poorly understood but the final outcome appears to be a mature syrinx filled with the cere-brospinal fluid with related neural tissue loss and permanent neurologic deficits. This paper re-views known pathologic mechanisms involved in the formation of the COI after SCI and discusses the integrative role of reactive astrogliosis in mechanisms involved in the removal of edema after the injury. A large proportion of edema fluid originating from the trauma and then from vasogenic edema related to persistent severe inflammation, may be moved into the COI in an active process involving astrogliosis and specifically over-expressed aquaporins.

Original languageEnglish (US)
Pages (from-to)294-303
Number of pages10
JournalCurrent Neuropharmacology
Issue number2
StatePublished - 2021


  • Aquaporins
  • Astrogliosis
  • Cavity of injury
  • Edema
  • Inflammation
  • Spinal cord injury
  • Syrinx

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


Dive into the research topics of 'The role of astrogliosis in formation of the syrinx in spinal cord injury'. Together they form a unique fingerprint.

Cite this