The resurgence of acyclic nucleic acids

Su Zhang, Christopher Switzer, John C. Chaput

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


This review examines acyclic nucleoside analogs as therapeutic agents, potential progenitor candidates to RNA, and novel building blocks for nucleic-acid nanotechnology. Together, these areas of research provide new insights into the structural and functional properties of nucleic acids and suggest new paradigms for nucleic acid self-assembly.

Original languageEnglish (US)
Pages (from-to)245-258
Number of pages14
JournalChemistry and Biodiversity
Issue number2
StatePublished - Feb 2010

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • General Chemistry
  • Molecular Medicine
  • Molecular Biology


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