The Powerful Functions of Peptide-Based Bioactive Matrices for Regenerative Medicine

Charles M. Rubert Pérez, Nicholas Stephanopoulos, Shantanu Sur, Sungsoo S. Lee, Christina Newcomb, Samuel I. Stupp

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


In an effort to develop bioactive matrices for regenerative medicine, peptides have been used widely to promote interactions with cells and elicit desired behaviors in vivo. This paper describes strategies that utilize peptide-based molecules as building blocks to create supramolecular nanostructures that emulate not only the architecture but also the chemistry of the extracellular matrix in mammalian biology. After initiating a desired regenerative response in vivo, the innate biodegradability of these systems allow for the natural biological processes to take over in order to promote formation of a new tissue without leaving a trace of the nonnatural components. These bioactive matrices can either bind or mimic growth factors or other protein ligands to elicit a cellular response, promote specific mechano-biological responses, and also guide the migration of cells with programmed directionality. In vivo applications discussed in this review using peptide-based matrices include the regeneration of axons after spinal cord injury, regeneration of bone, and the formation of blood vessels in ischemic muscle as a therapy in peripheral arterial disease and cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)501-514
Number of pages14
JournalAnnals of Biomedical Engineering
Issue number3
StatePublished - Mar 1 2015
Externally publishedYes


  • Bioactive peptides
  • Biomaterials
  • Regenerative medicine
  • Self-assembly
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering


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