TY - JOUR
T1 - The population genomics of within-host Mycobacterium tuberculosis
AU - Morales-Arce, Ana Y.
AU - Sabin, Susanna J.
AU - Stone, Anne C.
AU - Jensen, Jeffrey D.
N1 - Publisher Copyright:
© 2020, The Author(s), under exclusive licence to The Genetics Society.
PY - 2021/1
Y1 - 2021/1
N2 - Recent progress in genomic sequencing from patient samples has allowed for the first detailed insight into the within-host genetic diversity of Mycobacterium tuberculosis (M.TB), revealing remarkably low levels of variation. While this has often been attributed to low mutation rates, other factors have been described, including resistance evolution (i.e., selective sweeps), widespread purifying and background selection, and, more recently, progeny skew. Here we review recent findings pertaining to the processes governing the evolutionary dynamics of M.TB, discuss their implications for improving our understanding of this important human pathogen, and make recommendations for future work. Significantly, this emerging evolutionary framework involving the joint estimation of demographic, selective, and reproductive processes is forming a new paradigm for the study of within-host pathogen evolution that will be widely applicable across organisms.
AB - Recent progress in genomic sequencing from patient samples has allowed for the first detailed insight into the within-host genetic diversity of Mycobacterium tuberculosis (M.TB), revealing remarkably low levels of variation. While this has often been attributed to low mutation rates, other factors have been described, including resistance evolution (i.e., selective sweeps), widespread purifying and background selection, and, more recently, progeny skew. Here we review recent findings pertaining to the processes governing the evolutionary dynamics of M.TB, discuss their implications for improving our understanding of this important human pathogen, and make recommendations for future work. Significantly, this emerging evolutionary framework involving the joint estimation of demographic, selective, and reproductive processes is forming a new paradigm for the study of within-host pathogen evolution that will be widely applicable across organisms.
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U2 - 10.1038/s41437-020-00377-7
DO - 10.1038/s41437-020-00377-7
M3 - Review article
C2 - 33060846
AN - SCOPUS:85092674814
SN - 0018-067X
VL - 126
JO - Heredity
JF - Heredity
IS - 1
ER -