The molecular basis of colorectal carcinogenesis

Rebecca L. Shattuck-Brandt, Raymond N. DuBois

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing the role of four genes, APC, Cox-2, DCC/Smad4, and the mismatch repair genes, in colorectal carcinogenesis.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalCurrent Opinion in Gastroenterology
Issue number1
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'The molecular basis of colorectal carcinogenesis'. Together they form a unique fingerprint.

Cite this