TY - JOUR
T1 - The interactive effects of psychosocial stress and diet composition on health in primates
AU - Shively, Carol A.
AU - Frye, Brett M.
AU - Negrey, Jacob D.
AU - Johnson, Corbin S.C.
AU - Sutphen, Courtney L.
AU - Molina, Anthony J.A.
AU - Yadav, Hariom
AU - Snyder-Mackler, Noah
AU - Register, Thomas C.
N1 - Funding Information:
This work was supported by the National Institutes of Health RF1AG058829 , R01HL122393 , and R01HL087103 .
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/9
Y1 - 2023/9
N2 - Social disadvantage and diet composition independently impact myriad dimensions of health. They are closely entwined, as social disadvantage often yields poor diet quality, and may interact to fuel differential health outcomes. This paper reviews effects of psychosocial stress and diet composition on health in nonhuman primates and their implications for aging and human health. We examined the effects of social subordination stress and Mediterranean versus Western diet on multiple systems. We report that psychosocial stress and Western diet have independent and additive adverse effects on hypothalamic-pituitary-adrenal and autonomic nervous system reactivity to psychological stressors, brain structure, and ovarian function. Compared to the Mediterranean diet, the Western diet resulted in accelerated aging, nonalcoholic fatty liver disease, insulin resistance, gut microbial changes associated with increased disease risk, neuroinflammation, neuroanatomical perturbations, anxiety, and social isolation. This comprehensive, multisystem investigation lays the foundation for future investigations of the mechanistic underpinnings of psychosocial stress and diet effects on health, and advances the promise of the Mediterranean diet as a therapeutic intervention on psychosocial stress.
AB - Social disadvantage and diet composition independently impact myriad dimensions of health. They are closely entwined, as social disadvantage often yields poor diet quality, and may interact to fuel differential health outcomes. This paper reviews effects of psychosocial stress and diet composition on health in nonhuman primates and their implications for aging and human health. We examined the effects of social subordination stress and Mediterranean versus Western diet on multiple systems. We report that psychosocial stress and Western diet have independent and additive adverse effects on hypothalamic-pituitary-adrenal and autonomic nervous system reactivity to psychological stressors, brain structure, and ovarian function. Compared to the Mediterranean diet, the Western diet resulted in accelerated aging, nonalcoholic fatty liver disease, insulin resistance, gut microbial changes associated with increased disease risk, neuroinflammation, neuroanatomical perturbations, anxiety, and social isolation. This comprehensive, multisystem investigation lays the foundation for future investigations of the mechanistic underpinnings of psychosocial stress and diet effects on health, and advances the promise of the Mediterranean diet as a therapeutic intervention on psychosocial stress.
KW - Aging
KW - Anxiety
KW - Brain structure
KW - Mediterranean and Western diet
KW - Microbiome
KW - Mitochondria
KW - Neuroinflammation
KW - Nonhuman primates
KW - Ovarian function
KW - Psychosocial stress
KW - Social isolation
KW - Transcriptome
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U2 - 10.1016/j.neubiorev.2023.105320
DO - 10.1016/j.neubiorev.2023.105320
M3 - Review article
C2 - 37453725
AN - SCOPUS:85165473898
SN - 0149-7634
VL - 152
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 105320
ER -