Abstract
Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) DNA. Bryostatin 1 was administered i.v., both daily and weekly, and intralesionally both weekly and bi-weekly. Intralesionally dosed papillomas were examined histologically for immune cell infiltration. In weekly and daily i.v. trials, 2.5 and 1.0 μg/kg, respectively, showed the greatest overall reduction in tumor size. Bryostatin 1 administered intralesionally also slowed papilloma growth. Treated lesions had significantly higher numbers of heterophils and eosinophils. Copyright (C) 1999 Elsevier Science Ireland Ltd.
Original language | English (US) |
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Pages (from-to) | 67-74 |
Number of pages | 8 |
Journal | Cancer Letters |
Volume | 136 |
Issue number | 1 |
DOIs | |
State | Published - Feb 8 1999 |
Keywords
- Bryostatin 1
- Cancer therapeutics
- Cervical cancer
- PKC
- Papillomavirus
ASJC Scopus subject areas
- Oncology
- Cancer Research