@article{30d2f981cef34df5a447b7ad21118c68,
title = "The genomes of polyextremophilic cyanidiales contain 1% horizontally transferred genes with diverse adaptive functions",
abstract = "The role and extent of horizontal gene transfer (HGT) in eukaryotes are hotly disputed topics that impact our understanding of the origin of metabolic processes and the role of organelles in cellular evolution. We addressed this issue by analyzing 10 novel Cyanidiales genomes and determined that 1% of their gene inventory is HGT-derived. Numerous HGT candidates share a close phylogenetic relationship with prokaryotes that live in similar habitats as the Cyanidiales and encode functions related to polyextremophily. HGT candidates differ from native genes in GC-content, number of splice sites, and gene expression. HGT candidates are more prone to loss, which may explain the absence of a eukaryotic pan-genome. Therefore, the lack of a pan-genome and cumulative effects fail to provide substantive arguments against our hypothesis of recurring HGT followed by differential loss in eukaryotes. The maintenance of 1% HGTs, even under selection for genome reduction, underlines the importance of nonendosymbiosis related foreign gene acquisition.",
author = "Rossoni, {Alessandro W.} and Price, {Dana C.} and Mark Seger and Dagmar Lyska and Peter Lammers and Debashish Bhattacharya and Weber, {Andreas P.M.}",
note = "Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft (under Germany´s Excellence Strategy – EXC-2048/1 – Project ID: 390686111 and EXC 1028, and WE 2231/21-1 to A.P.M.W) and by the Heine Research Academy (A.W.R). We thank Dr. Luke Tallon and Dr. Bruno H{\"u}ttel for the excellent technical assistance for PacBio sequencing. Dr. Marion Eisenhut for her fantastic Power Point templates. D.C.P and D.B. are grateful to the Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft (under Germany´s Excellence Strategy – EXC-2048/1 – Project ID: 390686111 and EXC 1028, and WE 2231/21-1 to A.P.M.W) and by the Heine Research Academy (A.W.R). We thank Dr. Luke Tallon and Dr. Bruno H{\"u}ttel for the excellent technical assistance for PacBio sequencing. Dr. Marion Eisenhut for her fantastic Power Point templates. D.C.P and D.B. are grateful to the New Jersey Agricultural Experiment Station and the Rutgers University School of Environmental and Biological Sciences Genome Cooperative for supporting this research. Funding Information: Environmental and Biological Sciences Genome Cooperative for supporting this research. Publisher Copyright: {\textcopyright} 2019, eLife Sciences Publications Ltd. All rights reserved.",
year = "2019",
month = may,
doi = "10.7554/eLife.45017",
language = "English (US)",
volume = "8",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}