TY - JOUR
T1 - The effect of cognitive challenge on delay discounting
AU - Aranovich, Gabriel J.
AU - McClure, Samuel
AU - Fryer, Susanna
AU - Mathalon, Daniel H.
N1 - Funding Information:
This work was supported by grants NIMH R25MH060482 (to G.J. Aranovich), NSF 1358507 (to S.M. McClure), VA CSR&D : and IK2 CX001028 (S. Fryer), and NIMH R01 MH076989 (to D.H. Mathalon).
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Recent findings suggest that the dorsolateral prefrontal cortex (DLPFC), a region consistently associated with impulse control, is vulnerable to transient suppression of its activity and attendant functions by excessive stress and/or cognitive demand. Using functional magnetic resonance imaging, we show that a capacity-exceeding cognitive challenge induced decreased DLPFC activity and correlated increases in the preference for immediately available rewards. Consistent with growing evidence of a link between working memory capacity and delay discounting, the effect was inversely proportional to baseline performance on a working memory task. Subjects who performed well on the working memory task had unchanged, or even decreased, delay discounting rates, suggesting that working memory ability may protect cognitive control from cognitive challenge.
AB - Recent findings suggest that the dorsolateral prefrontal cortex (DLPFC), a region consistently associated with impulse control, is vulnerable to transient suppression of its activity and attendant functions by excessive stress and/or cognitive demand. Using functional magnetic resonance imaging, we show that a capacity-exceeding cognitive challenge induced decreased DLPFC activity and correlated increases in the preference for immediately available rewards. Consistent with growing evidence of a link between working memory capacity and delay discounting, the effect was inversely proportional to baseline performance on a working memory task. Subjects who performed well on the working memory task had unchanged, or even decreased, delay discounting rates, suggesting that working memory ability may protect cognitive control from cognitive challenge.
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U2 - 10.1016/j.neuroimage.2015.09.027
DO - 10.1016/j.neuroimage.2015.09.027
M3 - Article
C2 - 26394377
AN - SCOPUS:84943600844
SN - 1053-8119
VL - 124
SP - 733
EP - 739
JO - NeuroImage
JF - NeuroImage
ER -