Abstract
A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15. Reaction of protected (S)-Hiva-(S)-Phe 2c with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c → 3a) of the product in toluene and finally methylation afforded the key (S)-dolapyrrolidine (Dpy) derivative 3b. Condensation of tripeptide 8 with the three unit Dpy segment 5b followed by deprotection and coupling (diethyl phosphorocyanidate) led to dolastatin 15 in 11% overall yield. The powerful and selective activity of dolastatin 15 against the U.S. National Cancer Institute's panel of human cell lines has been summarized.
Original language | English (US) |
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Pages (from-to) | 12097-12108 |
Number of pages | 12 |
Journal | Tetrahedron |
Volume | 50 |
Issue number | 42 |
DOIs | |
State | Published - 1994 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry