Abstract
The South American Simaba cuspidata Spruce and North Indian Ailanthus granáis Prain were investigated as sources of potentially useful antineoplastic agents. Both of these Simaroubaceae plant species were found to produce 6a-tigloyloxychaparrinone (4a) and the new quassinoid 6a-tigloyloxychaparrin (3b). The latter structure was determined by interpretation of spectral data and oxidation to 6a-tigloyloxychaparrinone (4a). While both glycol 3b and -ketol 4a were found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell line, only the -ketol (4a) inhibited growth of the corresponding in vivo system.
Original language | English (US) |
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Pages (from-to) | 503-509 |
Number of pages | 7 |
Journal | Journal of Natural Products |
Volume | 43 |
Issue number | 4 |
DOIs | |
State | Published - Jul 1980 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry