The altered evolutionary trajectories of gene duplicates

Michael Lynch, Vaishali Katju

Research output: Contribution to journalArticlepeer-review

243 Scopus citations


Gene duplication is widely regarded as the predominant mechanism by which genes with new functions and associated phenotypic novelties arise. However, the mutational events and population-genetic mechanisms that lead to the short-term preservation of duplicate genes are not necessarily the same as those exhibited by well-established paralogs en route to the origin of new beneficial features. Thus, although recent genome-wide analyses have revealed striking patterns of protein-sequence divergence among the members of surviving paralogous gene families, the mechanisms responsible for the historical development of these patterns remain unclear.

Original languageEnglish (US)
Pages (from-to)544-549
Number of pages6
JournalTrends in Genetics
Issue number11
StatePublished - Nov 2004
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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