The Adaptor hypothesis revisited

Michael Ibba, Hubert D. Becker, Constantinos Stathopoulos, Debra L. Tumbula, Dieter Söll

Research output: Contribution to journalComment/debatepeer-review

108 Scopus citations


As originally postulated in Crick's Adaptor hypothesis, the faithful synthesis of proteins from messenger RNA is dependent on the presence of perfectly acylated tRNAs. The hypothesis also suggested that each aminoacyl-tRNA would be made by a unique enzyme. Recent data have now forced a revision of this latter point, with an increasingly diverse array of enzymes and pathways being implicated in aminoacyl-tRNA synthesis. These unexpected findings have far-reaching implications for our understanding of protein synthesis and its origins. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalTrends in Biochemical Sciences
Issue number7
StatePublished - Jul 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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