Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery

Derek J. Overstreet; Ryan Y. McLemore; Brandon D. Doan; Amye Farag; Brent Vernon

doi:10.1080/1539445X.2011.640731

Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery

Derek J. Overstreet, Ryan Y. McLemore, Brandon D. Doan, Amye Farag, Brent Vernon

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Temperature-responsive graft copolymers of N-isopropylacrylamide and Jeffamine® M-1000 acrylamide were synthesized to provide controlled swelling without introducing degradable moieties or increasing the LCST above body temperature. Jeffamine® M-1000 caused a small LCST increase (0.24-0.27°C/wt%) and a broader sol-gel transition. Twenty wt% copolymer gels (M_w> 225 kDa) retained their initial volume after 42 days, while homopolymer gels shrank by more than 50%. Copolymer gels eluted <20% of ovalbumin over 6 days whereas homopolymer gels released >90% within 3 h. These results suggest that Jeffamine® M-1000 acrylamide is suitable for inclusion in N-isopropylacrylamide-based biomaterials to control swelling and drug release nearly independently of LCST.

Original language	English (US)
Pages (from-to)	294-304
Number of pages	11
Journal	Soft Materials
Volume	11
Issue number	3
DOIs	https://doi.org/10.1080/1539445X.2011.640731
State	Published - Jul 1 2013

Keywords

Drug delivery
Graft copolymer
N -isopropylacrylamide
Swelling
Temperature-responsive polymer

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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10.1080/1539445X.2011.640731

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title = "Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery",

abstract = "Temperature-responsive graft copolymers of N-isopropylacrylamide and Jeffamine{\textregistered} M-1000 acrylamide were synthesized to provide controlled swelling without introducing degradable moieties or increasing the LCST above body temperature. Jeffamine{\textregistered} M-1000 caused a small LCST increase (0.24-0.27°C/wt%) and a broader sol-gel transition. Twenty wt% copolymer gels (Mw> 225 kDa) retained their initial volume after 42 days, while homopolymer gels shrank by more than 50%. Copolymer gels eluted <20% of ovalbumin over 6 days whereas homopolymer gels released >90% within 3 h. These results suggest that Jeffamine{\textregistered} M-1000 acrylamide is suitable for inclusion in N-isopropylacrylamide-based biomaterials to control swelling and drug release nearly independently of LCST.",

keywords = "Drug delivery, Graft copolymer, N -isopropylacrylamide, Swelling, Temperature-responsive polymer",

author = "Overstreet, {Derek J.} and McLemore, {Ryan Y.} and Doan, {Brandon D.} and Amye Farag and Brent Vernon",

note = "Funding Information: The authors acknowledge funding from the Arizona Biomedical Research Commission, Grant #0810, and a National Science Foundation GK-12 Down to Earth Science Graduate Fellowship (D.J.O.).",

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doi = "10.1080/1539445X.2011.640731",

language = "English (US)",

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T1 - Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery

AU - Overstreet, Derek J.

AU - McLemore, Ryan Y.

AU - Doan, Brandon D.

AU - Farag, Amye

AU - Vernon, Brent

N1 - Funding Information: The authors acknowledge funding from the Arizona Biomedical Research Commission, Grant #0810, and a National Science Foundation GK-12 Down to Earth Science Graduate Fellowship (D.J.O.).

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Temperature-responsive graft copolymers of N-isopropylacrylamide and Jeffamine® M-1000 acrylamide were synthesized to provide controlled swelling without introducing degradable moieties or increasing the LCST above body temperature. Jeffamine® M-1000 caused a small LCST increase (0.24-0.27°C/wt%) and a broader sol-gel transition. Twenty wt% copolymer gels (Mw> 225 kDa) retained their initial volume after 42 days, while homopolymer gels shrank by more than 50%. Copolymer gels eluted <20% of ovalbumin over 6 days whereas homopolymer gels released >90% within 3 h. These results suggest that Jeffamine® M-1000 acrylamide is suitable for inclusion in N-isopropylacrylamide-based biomaterials to control swelling and drug release nearly independently of LCST.

AB - Temperature-responsive graft copolymers of N-isopropylacrylamide and Jeffamine® M-1000 acrylamide were synthesized to provide controlled swelling without introducing degradable moieties or increasing the LCST above body temperature. Jeffamine® M-1000 caused a small LCST increase (0.24-0.27°C/wt%) and a broader sol-gel transition. Twenty wt% copolymer gels (Mw> 225 kDa) retained their initial volume after 42 days, while homopolymer gels shrank by more than 50%. Copolymer gels eluted <20% of ovalbumin over 6 days whereas homopolymer gels released >90% within 3 h. These results suggest that Jeffamine® M-1000 acrylamide is suitable for inclusion in N-isopropylacrylamide-based biomaterials to control swelling and drug release nearly independently of LCST.

KW - Drug delivery

KW - Graft copolymer

KW - N -isopropylacrylamide

KW - Swelling

KW - Temperature-responsive polymer

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DO - 10.1080/1539445X.2011.640731

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JO - Soft Materials

JF - Soft Materials

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ER -

Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery

Abstract

Keywords

ASJC Scopus subject areas

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