T-cell and chemokine receptor variation in South Amerindian populations

Tabita Hünemeier; Andrei G. Neves; Igor Nornberg; Kim Hill; A. Magdalena Hurtado; Francisco R. Carnese; Alicia S. Goicoechea; Mara H. Hutz; Francisco M. Salzano; José A.B. Chies

doi:10.1002/ajhb.20407

T-cell and chemokine receptor variation in South Amerindian populations

Tabita Hünemeier, Andrei G. Neves, Igor Nornberg, Kim Hill, A. Magdalena Hurtado, Francisco R. Carnese, Alicia S. Goicoechea, Mara H. Hutz, Francisco M. Salzano, José A.B. Chies

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The immune response of relatively small, endogamous populations is of special interest, because they may differ from those of large, ethnically diverse, urban groups. As a contribution to this area of investigation, we tested 99 individuals from two Brazilian native populations for two T-cell receptor gene segments (TCRBV3S1 and TCRBV18) and 241 subjects from eight tribes of this ethnic group in relation to the chemokine receptor CCR5Δ32 allele. Differences in TCRBV3S1 and TCRBV18 prevalences of the Amerindians in relation to European- and African-derived individuals were not marked. We confirmed the absence of the CCR5Δ32 allele in most groups, its presence in the Mura and Kaingang, probably because of European gene introgression.

Original language	English (US)
Pages (from-to)	515-518
Number of pages	4
Journal	American Journal of Human Biology
Volume	17
Issue number	4
DOIs	https://doi.org/10.1002/ajhb.20407
State	Published - Jul 2005
Externally published	Yes

ASJC Scopus subject areas

Anatomy
Ecology, Evolution, Behavior and Systematics
Anthropology
Genetics

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title = "T-cell and chemokine receptor variation in South Amerindian populations",

abstract = "The immune response of relatively small, endogamous populations is of special interest, because they may differ from those of large, ethnically diverse, urban groups. As a contribution to this area of investigation, we tested 99 individuals from two Brazilian native populations for two T-cell receptor gene segments (TCRBV3S1 and TCRBV18) and 241 subjects from eight tribes of this ethnic group in relation to the chemokine receptor CCR5Δ32 allele. Differences in TCRBV3S1 and TCRBV18 prevalences of the Amerindians in relation to European- and African-derived individuals were not marked. We confirmed the absence of the CCR5Δ32 allele in most groups, its presence in the Mura and Kaingang, probably because of European gene introgression.",

author = "Tabita H{\"u}nemeier and Neves, {Andrei G.} and Igor Nornberg and Kim Hill and Hurtado, {A. Magdalena} and Carnese, {Francisco R.} and Goicoechea, {Alicia S.} and Hutz, {Mara H.} and Salzano, {Francisco M.} and Chies, {Jos{\'e} A.B.}",

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T1 - T-cell and chemokine receptor variation in South Amerindian populations

AU - Hünemeier, Tabita

AU - Neves, Andrei G.

AU - Nornberg, Igor

AU - Hill, Kim

AU - Hurtado, A. Magdalena

AU - Carnese, Francisco R.

AU - Goicoechea, Alicia S.

AU - Hutz, Mara H.

AU - Salzano, Francisco M.

AU - Chies, José A.B.

PY - 2005/7

Y1 - 2005/7

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AB - The immune response of relatively small, endogamous populations is of special interest, because they may differ from those of large, ethnically diverse, urban groups. As a contribution to this area of investigation, we tested 99 individuals from two Brazilian native populations for two T-cell receptor gene segments (TCRBV3S1 and TCRBV18) and 241 subjects from eight tribes of this ethnic group in relation to the chemokine receptor CCR5Δ32 allele. Differences in TCRBV3S1 and TCRBV18 prevalences of the Amerindians in relation to European- and African-derived individuals were not marked. We confirmed the absence of the CCR5Δ32 allele in most groups, its presence in the Mura and Kaingang, probably because of European gene introgression.

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T-cell and chemokine receptor variation in South Amerindian populations

Abstract

ASJC Scopus subject areas

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