Synthesis of two mirror image 4-helix junctions derived from glycerol nucleic acid

Richard S. Zhang, Elizabeth O. McCullum, John C. Chaput

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Structural DNA nanotechnology relies on Watson-Crick base pairing rules to assemble DNA motifs into diverse arrangements of geometric shapes and patterns. While substantial effort has been devoted to expanding the programmability of natural DNA, considerably less attention has been given to the development of nucleic acid structures based on non-natural DNA polymers. Here we describe the use of glycerol nucleic acid (GNA), a simple polymer based on an acyclic repeating unit, as an alternative genetic material for assembling nucleic acid nanostructures independent of RNA or DNA recognition. We synthesized two 4-helix junctions based entirely on GNA self-pairing and showed that GNA provides easy access to highly stable nanostructures with left- and right-handed helical configurations.

Original languageEnglish (US)
Pages (from-to)5846-5847
Number of pages2
JournalJournal of the American Chemical Society
Issue number18
StatePublished - May 7 2008

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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