TY - JOUR
T1 - Synthesis of the cyclic heptapeptides Axinastatin 2 and Axinastatin 3
AU - Pettit, George
AU - Holman, Jeffrey W.
AU - Boland, Gerard M.
PY - 1996/10/7
Y1 - 1996/10/7
N2 - Practical total syntheses of axinastatins 2 2b and 3 2c were completed by employing Fmoc protection for the N-terminal, and tert-butyl ester blocking for the C-terminal, units of the amlno add and peptide intermediates. Generally, diethyl phosphorocyanidate proved effective for formation of the peptide bond, and in the one exception, asparagine, the o-nitrophenyl active ester proved to be useful. For the final cyclization reaction BOP-Cl was found especially effective.
AB - Practical total syntheses of axinastatins 2 2b and 3 2c were completed by employing Fmoc protection for the N-terminal, and tert-butyl ester blocking for the C-terminal, units of the amlno add and peptide intermediates. Generally, diethyl phosphorocyanidate proved effective for formation of the peptide bond, and in the one exception, asparagine, the o-nitrophenyl active ester proved to be useful. For the final cyclization reaction BOP-Cl was found especially effective.
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U2 - 10.1039/p19960002411
DO - 10.1039/p19960002411
M3 - Article
AN - SCOPUS:33748898277
SN - 0300-922X
SP - 2411
EP - 2416
JO - Journal of the Chemical Society - Perkin Transactions 1
JF - Journal of the Chemical Society - Perkin Transactions 1
IS - 19
ER -