Synthesis Of (+)-Isocombretastatins A-Cl

Sheo Bux Singh, George Pettit

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


With the African bush willow (Combretum caffrum) constituent R(-)-combretastatin (la) as a model syntheses of iso-combretastatins A(lb), B(1c) AND C(ld) were completed. Reaction (ultrasound promoted) between the lithium derivative of benzyl bromide 2b and silyl protected isovanillin 3a was illustrative of the general synthetic approach. Racemic isocombretastatin A was found to significantly inhibit (ed500.19-0.25μ g/ml) growth of the p388 lymphocytic leukemia cell line.

Original languageEnglish (US)
Pages (from-to)877-892
Number of pages16
JournalSynthetic Communications
Issue number7
StatePublished - May 1 1987

ASJC Scopus subject areas

  • Organic Chemistry


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