Synthesis and characterization of thermo-sensitive radio-opaque poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate)

Bae Hoon Lee; Christine Leon; Ryan McLemore; Jorge Valdez MacIas; Brent Vernon

doi:10.1163/092050610X539541

Synthesis and characterization of thermo-sensitive radio-opaque poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate)

Bae Hoon Lee, Christine Leon, Ryan McLemore, Jorge Valdez MacIas, Brent Vernon

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Radiopacity is required for embolic materials to be monitored by angiography during embolization. Covalently bound radio-opaque biomaterials would be ideal for embolization. Poly(N-isopropylacrylamide-co-PEG-acrylate) modified with 2-iodobenzoyl chloride was synthesized and characterized by ¹H-NMR, differential scanning calorimetry and X-ray opacity. Poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate) shows radiopacity, as well as thermo-sensitivity. Cytotoxicity testing on these co-polymers shows little cytotoxicity. Phase-transition temperature and radiopacity varied according to the content of NIPAAm and 2-iodobenzoate. Increasing the content of 2-iodobenzoate raised the radiopacity and lowered the LCST.

Original language	English (US)
Pages (from-to)	2357-2367
Number of pages	11
Journal	Journal of Biomaterials Science, Polymer Edition
Volume	22
Issue number	17
DOIs	https://doi.org/10.1163/092050610X539541
State	Published - 2011

Keywords

NIPAAm
Radio-opacity
thermo-responsive polymers

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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10.1163/092050610X539541

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title = "Synthesis and characterization of thermo-sensitive radio-opaque poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate)",

abstract = "Radiopacity is required for embolic materials to be monitored by angiography during embolization. Covalently bound radio-opaque biomaterials would be ideal for embolization. Poly(N-isopropylacrylamide-co-PEG-acrylate) modified with 2-iodobenzoyl chloride was synthesized and characterized by 1H-NMR, differential scanning calorimetry and X-ray opacity. Poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate) shows radiopacity, as well as thermo-sensitivity. Cytotoxicity testing on these co-polymers shows little cytotoxicity. Phase-transition temperature and radiopacity varied according to the content of NIPAAm and 2-iodobenzoate. Increasing the content of 2-iodobenzoate raised the radiopacity and lowered the LCST.",

keywords = "NIPAAm, Radio-opacity, thermo-responsive polymers",

author = "Lee, {Bae Hoon} and Christine Leon and Ryan McLemore and MacIas, {Jorge Valdez} and Brent Vernon",

note = "Funding Information: The authors acknowledge funding from the Arizona Biomedical Research Grant (No. 0810).",

year = "2011",

doi = "10.1163/092050610X539541",

language = "English (US)",

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AU - Lee, Bae Hoon

AU - Leon, Christine

AU - McLemore, Ryan

AU - MacIas, Jorge Valdez

AU - Vernon, Brent

N1 - Funding Information: The authors acknowledge funding from the Arizona Biomedical Research Grant (No. 0810).

PY - 2011

Y1 - 2011

N2 - Radiopacity is required for embolic materials to be monitored by angiography during embolization. Covalently bound radio-opaque biomaterials would be ideal for embolization. Poly(N-isopropylacrylamide-co-PEG-acrylate) modified with 2-iodobenzoyl chloride was synthesized and characterized by 1H-NMR, differential scanning calorimetry and X-ray opacity. Poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate) shows radiopacity, as well as thermo-sensitivity. Cytotoxicity testing on these co-polymers shows little cytotoxicity. Phase-transition temperature and radiopacity varied according to the content of NIPAAm and 2-iodobenzoate. Increasing the content of 2-iodobenzoate raised the radiopacity and lowered the LCST.

AB - Radiopacity is required for embolic materials to be monitored by angiography during embolization. Covalently bound radio-opaque biomaterials would be ideal for embolization. Poly(N-isopropylacrylamide-co-PEG-acrylate) modified with 2-iodobenzoyl chloride was synthesized and characterized by 1H-NMR, differential scanning calorimetry and X-ray opacity. Poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate) shows radiopacity, as well as thermo-sensitivity. Cytotoxicity testing on these co-polymers shows little cytotoxicity. Phase-transition temperature and radiopacity varied according to the content of NIPAAm and 2-iodobenzoate. Increasing the content of 2-iodobenzoate raised the radiopacity and lowered the LCST.

KW - NIPAAm

KW - Radio-opacity

KW - thermo-responsive polymers

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Synthesis and characterization of thermo-sensitive radio-opaque poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate)

Abstract

Keywords

ASJC Scopus subject areas

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