Synthesis and characterization of Mg-Ca-Sr alloys for biodegradable orthopedic implant applications

Ida S. Berglund, Harpreet S. Brar, Natalia Dolgova, Abhinav P. Acharya, Benjamin G. Keselowsky, Malisa Sarntinoranont, Michele V. Manuel

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Magnesium has recently received an increased amount of interest due to its potential use in biodegradable implant applications. The rapid degradation of conventional Mg is, however, a major limitation that needs to be addressed in the design of these materials, along with consideration of toxicity in selection of alloying elements. In this study, five alloys in the Mg-xCa-ySr system (x = 0.5-7.0 wt %; y = 0.5-3.5 wt %) were prepared and characterized for their suitability as degradable orthopedic implant materials. The alloys were characterized using optical microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, degradation measurements in Hanks' solution at 37°C, compression testing, and in vitro cytotoxicity testing with a mouse osteoblastic cell line. The results indicate that the Mg-1.0Ca-0.5Sr alloy is the most promising alloy for orthopedic implant applications since it showed the lowest degradation rate in Hanks' solution (0.01 mL cm-2 h-1) along with no significant toxicity to MC3T3-E1 osteoblasts and a compressive strength of 274 ± 4 MPa.

Original languageEnglish (US)
Pages (from-to)1524-1534
Number of pages11
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume100 B
Issue number6
StatePublished - Aug 2012
Externally publishedYes


  • cytotoxicity
  • magnesium-calcium-strontium alloys
  • orthopedic implant

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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