Supramolecular triblock copolymers containing complementary nucleobase molecular recognition

Brian D. Mather, Margaux B. Baker, Frederick L. Beyer, Michael A.G. Berg, Matthew D. Greeny, Timothy E. Long

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


A novel difunctional alkoxyamine initiator, DEPN2, was synthesized and utilized as an efficient initiator in nitroxide-mediated controlled radical polymerization of triblock copolymers. Complementary hydrogen-bonding triblock copolymers containing adenine (A) and thymine (T) nucleobase-functionalized outer blocks were synthesized. These thermoplastic elastomeric block copolymers contained short nucleobase-functionalized outer blocks (Mn ∼ 1K-4K) and n-butyl acrylate rubber blocks of variable length (Mn ∼ 14K-70K). Hydrogen-bonding interactions were observed for blends of the complementary nucleobase-functionalized block copolymers in terms of increased specific viscosity as well as higher scaling exponents for specific viscosity as a function of solution concentration. In the solid state, the blends exhibited evidence of a complementary A-T hard phase, which formed upon annealing, and dynamic mechanical analysis (DMA) revealed higher softening temperatures. Morphological development of the block copolymers was studied using SAXS and AFM, which revealed intermediate interdomain spacings and surface textures for the blends compared to the individual precursors. Hydrogen-bonding interactions enabled the compatibilization of complementary hydrogen-bonding guest molecules such as 9-octyladenine.

Original languageEnglish (US)
Pages (from-to)6834-6845
Number of pages12
Issue number19
StatePublished - Sep 18 2007
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry


Dive into the research topics of 'Supramolecular triblock copolymers containing complementary nucleobase molecular recognition'. Together they form a unique fingerprint.

Cite this