Suppressive effect of cyclophosphamide on the T cell system in chickens

J. M. Sharma, L. F. Lee

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Neonatal administration of 16 mg of cyclophosphamide in inbred chickens resulted in a transient, but profound, deficiency in the in vitro proliferative response of spleen cells. Functional T-cell deficiency was accompanied by a marked morphological degeneration in the thymus and thymus-dependent areas in the spleen.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalInfection and immunity
Issue number1
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


Dive into the research topics of 'Suppressive effect of cyclophosphamide on the T cell system in chickens'. Together they form a unique fingerprint.

Cite this