Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold

Nicholas G. Moon, Fiorella Mazzini, Allison M. Pekkanen, Emily M. Wilts, Timothy E. Long

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tgs of the polymer products; however, polymers did not exhibit Tgs above room temperature. Incorporating the comonomer N,N′-methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable-temperature fourier-transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.

Original languageEnglish (US)
Article number1800177
JournalMacromolecular Chemistry and Physics
Issue number16
StatePublished - Aug 2018
Externally publishedYes


  • Poly(β-thioester)
  • biomaterial
  • isosorbide
  • renewable feedstock
  • thiol-michael

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Materials Chemistry
  • Polymers and Plastics
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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