Studying Population Genetic Processes in Viruses: From Drug-Resistance Evolution to Patient Infection Dynamics

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

I here present a brief overview of the population genetic processes shaping within and between levels and patterns of variation and divergence in viral populations - emphasizing the importance of accounting for the constantly operating evolutionary processes of genetic drift (as modulated by infection dynamics) and purifying selection, prior to quantifying periodic evolutionary processes such as positive selection (associated with, for example, drug-resistance).

Original languageEnglish (US)
Title of host publicationEncyclopedia of Virology
Subtitle of host publicationVolume 1-5, Fourth Edition
PublisherElsevier
Pages227-232
Number of pages6
Volume1-5
ISBN (Electronic)9780128145166
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • Background selection
  • Coalescent theory
  • Demography
  • Direct selection
  • Genetic hitchhiking
  • Genomic scans for selection
  • Hill-Robertson interference
  • Kingman coalescent
  • Linked selection effects
  • Multiple-merger coalescent
  • Population genetics
  • Selective sweeps

ASJC Scopus subject areas

  • General Immunology and Microbiology

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