Abstract
A series of glycosylated serine derivatives was synthesized from peracetylated sugars and Fmoc-protected serine; these were chemically esterified with the tris-(tetrabutylammonium) salt of pdCpA. The fully protected and deprotected glycosylated aminoacyl pdCpAs were ligated enzymatically to an abbreviated tRNA (tRNA-COH) to provide the title compounds that are key intermediates in the elaboration of glycoproteins using readthrough of a nonsense codon.
Original language | English (US) |
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Pages (from-to) | 149-164 |
Number of pages | 16 |
Journal | Carbohydrate Research |
Volume | 330 |
Issue number | 2 |
DOIs | |
State | Published - Jan 30 2001 |
Externally published | Yes |
Keywords
- Glycoprotein
- Monosaccharide
- S-serine
- Site-specific glycosylation
- Transfer RNA
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Organic Chemistry