Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore

James McNulty; Justin Mao; Romelo Gibe; Ruowei Mo; Sonja Wolf; George Pettit; Delbert L. Herald; Michael R. Boyd

doi:10.1016/S0960-894X(00)00614-4

Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore

James McNulty, Justin Mao, Romelo Gibe, Ruowei Mo, Sonja Wolf, George Pettit, Delbert L. Herald, Michael R. Boyd

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.

Original language	English (US)
Pages (from-to)	169-172
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(00)00614-4
State	Published - Jan 22 2001

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00614-4

Cite this

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title = "Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore",

abstract = "Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.",

author = "James McNulty and Justin Mao and Romelo Gibe and Ruowei Mo and Sonja Wolf and George Pettit and Herald, {Delbert L.} and Boyd, {Michael R.}",

note = "Funding Information: Financial support from the Natural Sciences and Engineering Research Council of Canada, Research Corporation (Cottrell Scholar Science Award to J.McN) and the Canada Foundation for Innovation are gratefully acknowledged. One of us (G.R.P.) wishes to thank the Arizona Disease Control Research Commission and Outstanding Investigator Grant CA-44344-10-12 awarded by the DCTD, National Cancer Institute, DHHS. We thank Mr. Tim Jones for conducting MS and 2D-NMR analyses.",

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doi = "10.1016/S0960-894X(00)00614-4",

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AU - McNulty, James

AU - Mao, Justin

AU - Gibe, Romelo

AU - Mo, Ruowei

AU - Wolf, Sonja

AU - Pettit, George

AU - Herald, Delbert L.

AU - Boyd, Michael R.

N1 - Funding Information: Financial support from the Natural Sciences and Engineering Research Council of Canada, Research Corporation (Cottrell Scholar Science Award to J.McN) and the Canada Foundation for Innovation are gratefully acknowledged. One of us (G.R.P.) wishes to thank the Arizona Disease Control Research Commission and Outstanding Investigator Grant CA-44344-10-12 awarded by the DCTD, National Cancer Institute, DHHS. We thank Mr. Tim Jones for conducting MS and 2D-NMR analyses.

PY - 2001/1/22

Y1 - 2001/1/22

N2 - Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.

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Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore

Abstract

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CCDC 160158: Experimental Crystal Structure Determination

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Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore

Abstract

ASJC Scopus subject areas

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Datasets

CCDC 160158: Experimental Crystal Structure Determination

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