Structure-guided identification of a peptide for bio-enabled gold nanoparticle synthesis

Amar Thaker, Luqmanal Sirajudeen, Chad R. Simmons, Brent L. Nannenga

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


In this study, we show that maltose-binding protein (MBP) is capable of facilitating stable gold nanoparticle synthesis, and a structure of MBP in the presence of gold ions was determined by X-ray crystallography. Using this high-resolution structure of gold ion bound MBP, a peptide (AT1) was selected and synthesized and was shown to also aid in the synthesis of stable gold nanoparticles under similar experimental conditions to those used for protein facilitated synthesis. This structure-based approach represents a new potential method for the selection of peptides capable of facilitating stable nanoparticle synthesis.

Original languageEnglish (US)
Pages (from-to)4867-4873
Number of pages7
JournalBiotechnology and bioengineering
Issue number12
StatePublished - Dec 2021


  • biomineralization
  • gold nanoparticles
  • nanobiotechnology
  • protein crystallography

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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