Streptomyces: a host for heterologous gene expression

Mary Brawner, George Poste, Martin Rosenberg, Janet Westpheling

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Streptomyces species offer many potential advantages as hosts for the expression and secretion of eukaryotic gene products. In this review we discuss the expression and localization signals that have been used to direct heterologous gene expression and the applications of these signals. Finally, we discuss future strategies aimed at increasing the capacity of this host for the high level production of biologically active eukaryotic gene products.

Original languageEnglish (US)
Pages (from-to)674-681
Number of pages8
JournalCurrent Opinion in Biotechnology
Issue number5
StatePublished - Oct 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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