Œstrone has been converted into 14α-methylœstr-4-ene-3, 15-dione (V) in 14 steps. Direct alkylation at position 14 (activated by a 15-oxo-group) proved convenient for introducing the angular methyl group. Configuration of the 14-methyl substituent was established by o.r.d. measurements.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of the Chemical Society C: Organic Chemistry|
|State||Published - 1967|
ASJC Scopus subject areas
- Organic Chemistry