Stereoselective synthesis of the atropisomers of myristinin B/C

David J. Maloney; Shengxi Chen; Sidney M. Hecht

doi:10.1021/ol060511b

Stereoselective synthesis of the atropisomers of myristinin B/C

David J. Maloney, Shengxi Chen, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The first stereoselective synthesis of a potent DNA damaging agent, (-)-myristinin B/C, has been accomplished. This efficient synthesis allowed for unambiguous confirmation of the structure and absolute stereochemistry of the atropisomeric natural product. The antipode, (+)-myristinin B/C, was also synthesized, providing ample material for biological evaluation of both enantiomers.

Original language	English (US)
Pages (from-to)	1925-1927
Number of pages	3
Journal	Organic Letters
Volume	8
Issue number	9
DOIs	https://doi.org/10.1021/ol060511b
State	Published - Apr 27 2006
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol060511b

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title = "Stereoselective synthesis of the atropisomers of myristinin B/C",

abstract = "The first stereoselective synthesis of a potent DNA damaging agent, (-)-myristinin B/C, has been accomplished. This efficient synthesis allowed for unambiguous confirmation of the structure and absolute stereochemistry of the atropisomeric natural product. The antipode, (+)-myristinin B/C, was also synthesized, providing ample material for biological evaluation of both enantiomers.",

author = "Maloney, {David J.} and Shengxi Chen and Hecht, {Sidney M.}",

year = "2006",

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AU - Maloney, David J.

AU - Chen, Shengxi

AU - Hecht, Sidney M.

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Y1 - 2006/4/27

N2 - The first stereoselective synthesis of a potent DNA damaging agent, (-)-myristinin B/C, has been accomplished. This efficient synthesis allowed for unambiguous confirmation of the structure and absolute stereochemistry of the atropisomeric natural product. The antipode, (+)-myristinin B/C, was also synthesized, providing ample material for biological evaluation of both enantiomers.

AB - The first stereoselective synthesis of a potent DNA damaging agent, (-)-myristinin B/C, has been accomplished. This efficient synthesis allowed for unambiguous confirmation of the structure and absolute stereochemistry of the atropisomeric natural product. The antipode, (+)-myristinin B/C, was also synthesized, providing ample material for biological evaluation of both enantiomers.

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JO - Organic Letters

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Stereoselective synthesis of the atropisomers of myristinin B/C

Abstract

ASJC Scopus subject areas

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