Stepping into the Next Dimension of Biomaterial Design

Julianne L. Holloway

doi:10.1016/j.tibtech.2019.10.003

Stepping into the Next Dimension of Biomaterial Design

Julianne L. Holloway

Engineering, Ira A. Fulton Schools of (IAFSE)

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Recapitulating the dynamic spatiotemporal behavior of the extracellular matrix using biomaterials is an ongoing challenge. A recent breakthrough by Shadish et al. demonstrates the use of sortase-mediated transpeptidation to site-specifically modify proteins with a range of chemical motifs. Modified proteins were immobilized within biomaterials with high spatiotemporal control and resulted in localized bioactivity.

Original language	English (US)
Pages (from-to)	1276-1278
Number of pages	3
Journal	Trends in Biotechnology
Volume	37
Issue number	12
DOIs	https://doi.org/10.1016/j.tibtech.2019.10.003
State	Published - Dec 2019

Keywords

biomaterials
patterning
protein immobilization
spatiotemporal control

ASJC Scopus subject areas

Biotechnology
Bioengineering

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10.1016/j.tibtech.2019.10.003

Cite this

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title = "Stepping into the Next Dimension of Biomaterial Design",

abstract = "Recapitulating the dynamic spatiotemporal behavior of the extracellular matrix using biomaterials is an ongoing challenge. A recent breakthrough by Shadish et al. demonstrates the use of sortase-mediated transpeptidation to site-specifically modify proteins with a range of chemical motifs. Modified proteins were immobilized within biomaterials with high spatiotemporal control and resulted in localized bioactivity.",

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AB - Recapitulating the dynamic spatiotemporal behavior of the extracellular matrix using biomaterials is an ongoing challenge. A recent breakthrough by Shadish et al. demonstrates the use of sortase-mediated transpeptidation to site-specifically modify proteins with a range of chemical motifs. Modified proteins were immobilized within biomaterials with high spatiotemporal control and resulted in localized bioactivity.

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KW - protein immobilization

KW - spatiotemporal control

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Stepping into the Next Dimension of Biomaterial Design

Abstract

Keywords

ASJC Scopus subject areas

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